Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team has now gained new insights into the DNA damage response. Whenever cells ...

Cedars-Sinai scientists have developed an experimental drug that repairs DNA and serves as a prototype for a new class of medications that fix tissue damage caused by heart attack, inflammatory ...

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both sides of the DNA helix are cut at once. Healthy cells can normally fix ...

New research sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells. The study demonstrates how these proteins ...

Organisms like eukaryotes and prokaryotes have sophisticated mechanisms of DNA repair after damage. Failure of repairing the DNA damage is considered to be the cause of induction of cell death, ...

A research team led by Professor ZHAO Guoping at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, has unveiled a crucial mechanism that helps regulate DNA damage repair, ...

ADP-ribosylation, the attachment of ADP-ribose to proteins, is a common eukaryotic post-translational modification. It exists in two forms: mono ADP-ribosylation (MARylation), where individual units ...

A recent study in Nature Communications examined how RNA polymerase I (Pol I) responds to abasic (Ap) site formation—the most common type of DNA damage. The researchers found that Pol I helps maintain ...

Research from scientists at Albert Einstein College of Medicine, Northwestern University, and elsewhere indicates that forming long-term memories requires DNA damage and brain inflammation. The ...